Title of article
Novel triethylsilane mediated reductive N-alkylation of amines: improved synthesis of 1-(4-imidazolyl)methyl-4-sulfonylbenzodiazepines, new farnesyltransferase inhibitors
Author/Authors
Chen، نويسنده , , Bang-Chi and Sundeen، نويسنده , , Joseph E and Guo، نويسنده , , Peng and Bednarz، نويسنده , , Mark N. and Zhao، نويسنده , , Rulin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
2
From page
1245
To page
1246
Abstract
An improved synthesis of 1-(imidazolyl)methyl-4-sulfonylbenzodiazapines, new farnesyltransferase inhibitors, was achieved using a novel reductive N-alkylation method. The new method involves reaction of a secondary amine with an aldehyde using triethylsilane in the presence of trifluoroacetic acid, giving a tertiary amine in 90–95% isolated yields.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641888
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