Author/Authors :
Smith، نويسنده , , Mark E.B and Derrien، نويسنده , , Nadine and Lloyd، نويسنده , , Michael C and Taylor، نويسنده , , Stephen J.C and Chaplin، نويسنده , , David A and McCague، نويسنده , , Raymond، نويسنده ,
Abstract :
The use of both N-tert-butoxycarbonylamino- and hydroxyl-directed hydrogenation methodology to yield essentially single diastereomers of 3-(tert-butoxycarbonylamino)-4-hydroxycyclopentanecarboxylic acid methyl esters and 3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid methyl esters is described. These results incorporate the first reported carbamate-directed hydrogenations of functionalised cyclopentenes.
