Author/Authors :
Carnell، نويسنده , , Andrew J and Escudero Hernandez، نويسنده , , Maria Luisa and Pettman، نويسنده , , Alan and Bickley، نويسنده , , Jamie F، نويسنده ,
Abstract :
The synthesis of a tachykinin NK-2 antagonist (S)-11 has been carried out in four steps starting from the the (S)-(+)-enol acetate 3, which was obtained in 100% e.e. by resolution of the racemic ester with Pseudomonas fluorescens lipase. The absolute configuration of the enol acetate (+)-3 was confirmed by X-ray analysis of the camphanyl derivative 13.
