Chemiluminescence of chlorpromazine hydrochloride based on cerium(IV) oxidation sensitized by rhodamine 6G

A new chemiluminescence (CL) method is proposed for the determination of chlorpromazine hydrochloride, a drug often used to treat the psychiatric patients suffering from clinical depression. The method is based on the reaction between studied drug and Ce(IV) in a nitric acid medium and measurement of the CL intensity produced by rhodamine 6G used as a sensitizer. In the optimum conditions, CL intensities are proportional to concentrations of the studied drug over the range 0–1×10−5 g ml−1 with a detection limit of 6.5×10−9 g ml−1. The relative standard deviation (R.S.D.) is 4.1% for 1.5×10−6 g ml−1 chlorpromazine hydrochloride (n=11). The method has been applied to the determination of studied drug in tablets and biological fluids with satisfactory results.