Title of article
Total synthesis of madindoline A
Author/Authors
Hosokawa، نويسنده , , Seijiro and Sekiguchi، نويسنده , , Kazuhiko and Hayase، نويسنده , , Kanako and Hirukawa، نويسنده , , Yasushi and Kobayashi، نويسنده , , Susumu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
6435
To page
6439
Abstract
The total synthesis of madindoline A was achieved. The key step of the synthesis is a reductive coupling of an acid-sensitive hydroxyfuroindoline derivative and a sterically hindered aldehyde using Sn(OTf)2–NaBH(OAc)3. After the reductive coupling, the derived trione was subjected to intramolecular condensation to construct a madindoline skeleton.
Keywords
madindoline A , total synthesis , tin(II) triflate , reductive coupling , intramolecular condensation
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1642770
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