Title of article
Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection
Author/Authors
Boldrini، نويسنده , , Vincenzo and Giovenzana، نويسنده , , Giovanni B and Pagliarin، نويسنده , , Roberto and Palmisano، نويسنده , , Giovanni and Sisti، نويسنده , , Massimo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
6527
To page
6530
Abstract
The reaction of cyclen 1 with chloral hydrate afforded exclusively 1,4,7-triformylcyclen 2 in high yield; the triprotected macrocycle was easily alkylated with various electrophiles in good to excellent yields. The alkaline removal of the formyl groups provided a selective entry into N-monosubstituted cyclen derivatives.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1642808
Link To Document