Glycosylation study on pradimicin–benanomicin antibiotics

In relation to the synthesis of the pradimicin–benanomicin antibiotics, a model study was carried out for introducing the disaccharide moiety. The glycosyl donor 2, prepared from d-glucose and d-xylose, was allowed to react with various glycosyl acceptors in the presence of Cp2HfCl2 and AgClO4. Also studied was the reactivity difference between the conformers of the trans-phenanthrendiol derivatives 12, 13 and 14.