Title of article
Chemoenzymatic synthesis of a non-peptide tachykinin NK-2 antagonist
Author/Authors
Carnell، نويسنده , , Andrew J and Escudero Hernandez، نويسنده , , Maria Luisa and Pettman، نويسنده , , Alan and Bickley، نويسنده , , Jamie F، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
6929
To page
6933
Abstract
The synthesis of a tachykinin NK-2 antagonist (S)-11 has been carried out in four steps starting from the the (S)-(+)-enol acetate 3, which was obtained in 100% e.e. by resolution of the racemic ester with Pseudomonas fluorescens lipase. The absolute configuration of the enol acetate (+)-3 was confirmed by X-ray analysis of the camphanyl derivative 13.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1643014
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