Title of article
Deprotection of N-tert-butoxycarbonyl (Boc) groups in the presence of tert-butyl esters
Author/Authors
Lin، نويسنده , , Linus S and Lanza Jr.، نويسنده , , Thomas and de Laszlo، نويسنده , , Stephen E and Truong، نويسنده , , Quang and Kamenecka، نويسنده , , Theodore and Hagmann، نويسنده , , William K، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
7013
To page
7016
Abstract
Deprotection of Boc groups in the presence of tert-butyl esters was achieved by using concentrated H2SO4 (1.5–3.0 equiv.) in tBuOAc or MeSO3H (1.5–3.0 equiv.) in tBuOAc:CH2Cl2 (4:1 v/v). The yields ranged from 70 to 100% for a variety of amino acid and dipeptide substrates.
Keywords
amino acids and derivatives , deblocking , protecting groups
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1643055
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