• Title of article

    Synthetic routes to NEtXaa4-cyclosporin A derivatives as potential anti-HIV I drugs

  • Author/Authors

    Hubler، نويسنده , , Francis and Rückle، نويسنده , , Thomas and Patiny، نويسنده , , Luc and Muamba، نويسنده , , Tshilolo and Guichou، نويسنده , , Jean-François and Mutter، نويسنده , , Manfred and Wenger، نويسنده , , Roland، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2000
  • Pages
    4
  • From page
    7193
  • To page
    7196
  • Abstract
    An efficient synthesis in 10 steps and overall yields up to 27% of NEtXaa4-cyclosporin A derivatives (Xaa=Leu, Val, Ile, Thr) starting from cyclosporin A is described. Biological activities of the new analogues show promising results for the design of cyclosporin derivatives exhibiting non-immunosuppressive and anti-HIV activity.
  • Keywords
    cyclosporin A derivatives , Anti-HIV drug , N-ethyl amino acids
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2000
  • Journal title
    Tetrahedron Letters
  • Record number

    1643127

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1643127