Title of article
Total synthesis of a Pepstatin analogue incorporating two trifluoromethyl hydroxymethylene isosteres
Author/Authors
Pesenti، نويسنده , , Cristina and Arnone، نويسنده , , Alberto and Aubertin، نويسنده , , Anne Marie and Bravo، نويسنده , , Pierfrancesco and Frigerio، نويسنده , , Massimo and Panzeri، نويسنده , , Walter F. Schmidt، نويسنده , , Sylvie and Viani، نويسنده , , Fiorenza and Zanda *، نويسنده , , Matteo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
7239
To page
7243
Abstract
The total synthesis of a trifluoromethyl (Tfm) analogue of the aspartate protease inhibitor Pepstatin has been accomplished via incorporation of two α-Tfm-amino β-hydroxy peptide isosteres instead of the natural statine units. The title compound as well as several Tfm-substituted precursors did not show anti-HIV activity.
Keywords
pepstatin , peptide mimetics , Enzyme inhibitors , Trifluoromethyl group
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1643153
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