Title of article
A synthesis of trifluoromethyl-substituted naphthalenes
Author/Authors
Mellor، نويسنده , , John M and El-Sagheer، نويسنده , , Afaf H and Salem، نويسنده , , Ezz El-Din M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
7383
To page
7386
Abstract
Alkyl and aryl Grignard reagents add to 1-(3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone by 1,4-addition, but benzyl Grignard reagents react in good yield by 1,2-addition. Dehydration of the resulting alcohols affords intermediate dienes, which readily undergo cyclisation to give substituted trifluoromethylnaphthalenes. Addition to other trifluoromethylketones permits access to a range of novel fluorinated naphthalenes and benzenes.
Keywords
additions , Grignard reagents , Trifluoromethylketones , Naphthalenes
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1643191
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