Author/Authors :
Matsumura، نويسنده , , Ryuji and Suzuki، نويسنده , , Toshio and Hagiwara، نويسنده , , Hisahiro and Hoshi، نويسنده , , Takashi and Ando، نويسنده , , Masayoshi، نويسنده ,
Abstract :
The first total synthesis of (+)-rogioloxepane A is described. The α,ω-trans-disubstituted oxepene skeleton was stereoselectively constructed via cyclization of the hydroxy epoxide promoted by the (Bu3Sn)2O/Zn(OTf)2 system. The proposed configurations of 6R and 13R were confirmed through this synthetic study.
Keywords :
cyclization , natural products , oxepanes , medium-ring heterocycles
