Author/Authors :
Martin J Deetz، نويسنده , , Martin J and Malerich، نويسنده , , Jeremiah P and Beatty، نويسنده , , Alicia M and Smith، نويسنده , , Bradley D، نويسنده ,
Abstract :
2-Fluoro substituted benzoyl chlorides undergo cyclocondensation with 2-amino-N-heterocycles to form 4(3H)-quinazolinones. The reaction proceeds in moderate yields with different combinations of benzoyl chlorides and 2-amino-N-heterocycles. The products generally precipitate from the reaction mixture and require no further purification. Two tetrafluoro quinazolinones were found to be moderately active against a number of tumor cell lines.
