Title of article :
N-Fluorocinchonidinium tetrafluoroborate F-CD-BF4: purification and structure elucidation of this novel enantioselective electrophilic fluorinating agent
Author/Authors :
Cahard، نويسنده , , Dominique and Audouard، نويسنده , , Christophe and Plaquevent، نويسنده , , Jean-Christophe and Toupet، نويسنده , , Loic and Roques، نويسنده , , Nicolas، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
The first ever enantiopure N-fluoro quaternary ammonium salt of cinchonidine (F-CD-BF4) was prepared as an enantioselective fluorinating agent. A one-step transfer-fluorination of the quinuclidine moiety with Selectfluor® gave the [NF]+ reagent. The X-ray structure of F-CD-BF4 was determined, which shows the NF distance (1.409(7) Å) close to that found in other NF compounds.
Keywords :
Alkaloids , Fluorine compounds , Halogenation , X-ray crystallography , Enantioselection
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
