New NADH models bearing a phosphonate or a chiral oxazaphospholidine oxide at the dihydropyridine ring

Novel NADH models bearing a phosphonate at the 3-position of a stable 1,4-dihydroquinoline structure were successfully involved in the reduction of methyl benzoylformate. Asymmetric reduction of the former ketone with a NADH model bearing a chiral oxazaphospholidine oxide is reported affording methyl benzoylformate in 45% e.e.