Author/Authors :
Zhao، نويسنده , , Rulin and Gove، نويسنده , , Stacey and Sundeen، نويسنده , , Joseph E and Chen، نويسنده , , Bang-Chi، نويسنده ,
Abstract :
A new facile method has been developed for the synthesis of 2-aminothiazole-5-carboxylates. The new method involves reaction of ethyl β-ethoxyacrylate with N-bromosuccinimide (NBS) to give a novel intermediate, α-bromo-α-formylacetate hemiacetal. Cyclization of the in situ formed hemiacetal with thioureas afforded 2-aminothiazole-5-carboxylates in 60–98% yields.
