Title of article
A Dde-based carboxy linker for solid-phase synthesis
Author/Authors
Chhabra، نويسنده , , Siri Ram and Parekh، نويسنده , , Harendra and Khan، نويسنده , , Azra N and Bycroft، نويسنده , , Barrie W and Kellam، نويسنده , , Barrie، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
2189
To page
2192
Abstract
The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and its utility illustrated by the construction of model peptides, Leu-enkephalin and Human Angiotensin II.
Keywords
carboxylic acids , solid-phase synthesis , supported reagents/reactions , linkers
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1643795
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