Title of article
Synthesis of biotinylated glycosulfopeptides by chemoselective ligation
Author/Authors
Durieux، نويسنده , , Patricia and Fernandez-Carneado، نويسنده , , Jimena and Tuchscherer، نويسنده , , Gabriele، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
2297
To page
2299
Abstract
Tyrosine sulfation and O-glycosylation are two post-translational modifications playing an essential role in modulation of biological activity, protein folding and cellular communication. Here, a novel chemical approach for the synthesis of biotinylated glycosulfopeptides is described based on a combination of acid labile protecting groups, highly acid sensitive resins and two orthogonal chemoselective ligation reactions.
Keywords
Chemoselective ligation , biotinylated glycosulfopeptides , PSGL-1 mimetics , peptide conjugates
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1643866
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