Title of article
Practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA) via a purine 3′-deoxynucleoside
Author/Authors
Takamatsu، نويسنده , , Satoshi and Maruyama، نويسنده , , Tokumi and Katayama، نويسنده , , Satoshi and Hirose، نويسنده , , Naoko and Naito، نويسنده , , Masaki and Izawa، نويسنده , , Kunisuke، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
2325
To page
2328
Abstract
A practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (1, FddA) via a 6-chloro-9-(3-deoxy-β-d-erythro-pentofuranosyl)-9H-purine (6) is described. Fluorination at the C2′-β position of the purine 3′-deoxynucleoside was improved by the introduction of 6-chloro group, and proceeded in moderate yield. The total yield of FddA from readily available starting material 6 was 35%.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1643885
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