Title of article
Synthesis of a new transition-state analog of the sialyl donor. Inhibition of sialyltransferases
Author/Authors
Sun، نويسنده , , Hongbin and Yang، نويسنده , , Jingsong and Amaral، نويسنده , , Katie E and Horenstein، نويسنده , , Benjamin A، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
2451
To page
2453
Abstract
A new class of glycosyltransferase inhibitor has been designed and synthesized. The designed inhibitors 3a/3b provide conformational mimicry of the transition state in sialyltransfer reactions. The key synthetic steps involve a Meinwald rearrangement and a palladium-catalyzed carbonylation reaction. The results of kinetic studies show that 3a/3b exhibit significant inhibition on both 2,3- and 2,6-sialytransferases.
Keywords
transition states , Inhibitors , glycosyltransferases , sialytransferases , Synthesis
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1643962
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