Solid-phase synthesis of peptide aldehydes directly on acetal resin

A practical strategy for solid-phase synthesis of peptide aldehydes has been developed employing a 10,11-dihydroxyundecanoic acid (DHUA) functionalized resin. High loading levels are obtained for amino aldehydes as their respective acetals. After classical Fmoc SPPS, treatment of the derivatized resin with 95% TFA/H2O affords peptide aldehydes in high yield and purity.