Title of article
1,3,4-Oxadiazole formation; a novel solid support strategy
Author/Authors
Kilburn، نويسنده , , John P and Lau، نويسنده , , Jesper and Jones، نويسنده , , Raymond C.F. Jones، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
2583
To page
2586
Abstract
A new approach to the synthesis of 1,3,4-oxadiazoles on solid support is described. Resin bound 1-acyl thiosemicarbazides were treated with a variety of dehydrating agents at different temperatures, which revealed that thiosemicarbazides were effectively cyclised by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl); mild acidic cleavage from the solid support released the substituted 1,3,4-oxadiazoles in excellent purity.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1644046
Link To Document