Solid phase synthesis of chiral 2-amino-benzimidazoles

A multi-step solid phase synthesis of 2-aminobenzimidazoles is described. The reaction sequence incorporates optically active α-amino acids to afford enantiomerically pure 2-aminobenzimidazoles with a chiral center adjacent to one of the heterocyclic nitrogens. This solid phase methodology has been further extended to prepare other chiral heterocyclic compounds such as benzimidazolones.