Title of article
Mechanistic and stereochemical aspects of the Lewis acid mediated cleavage of α-aminoacetals
Author/Authors
Graham ، نويسنده , , Mark A and Wadsworth، نويسنده , , Alan H and Thornton-Pett، نويسنده , , Mark and Carrozzini، نويسنده , , Benedetta and Cascarano، نويسنده , , Giovanni L and Rayner، نويسنده , , Christopher M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
2865
To page
2868
Abstract
The TMSOTf mediated nucleophilic cleavage of α-aminoacetals can be used to prepare a variety of substituted amines, with variable levels of stereocontrol depending on the substitution patterns. The reaction most likely proceeds via either an α-alkoxy aziridinium ion or an α-oxocarbenium ion depending on the type of nucleophile.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1644324
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