Title of article :
Synthesis of 4-demethoxyadriamycinone utilizing ruthenium-catalyzed oxidation of allyl acetates
Author/Authors :
Hottop، نويسنده , , Torsten and Gutke، نويسنده , , Hans-Jürgen and Murahashi، نويسنده , , Shun-Ichi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
A new method for the construction of the side chain of anti-cancer drugs adriamycins is demonstrated by the synthesis of 4-demethoxyadriamycinone. The key step is the ruthenium-catalyzed oxidation of allyl acetates to the corresponding α-hydroxyketones.
Keywords :
ruthenium-catalyzed oxidation , 4-demethoxyadriamycinone , anthracyclinone , ?-ketol
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
