Author/Authors :
Black، نويسنده , , Gregory P and Coles، نويسنده , , Simon J and Hizi، نويسنده , , Amnon and Howard-Jones، نويسنده , , Andrew G and Hursthouse، نويسنده , , Michael B and McGown، نويسنده , , Alan T and Loya، نويسنده , , Shoshana and Moore، نويسنده , , Christopher G and Murphy، نويسنده , , Patrick J and Smith، نويسنده , , Nigel K and Walshe، نويسنده , , Nigel D.A، نويسنده ,
Abstract :
Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT).
