Title of article
A convenient synthesis of N-Fmoc-N,N′-bis-Boc-7-guanyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (Fmoc-N,N′-bis-Boc-7-guanyl-Tic-OH, GTIC)
Author/Authors
Santagada، نويسنده , , Vincenzo and Fiorino، نويسنده , , Ferdinando and Severino، نويسنده , , Beatrice and Salvadori، نويسنده , , Severo and Lazarus، نويسنده , , Lawrence H and Bryant، نويسنده , , Sharon D and Caliendo، نويسنده , , Giuseppe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
3507
To page
3509
Abstract
Fmoc-N,N′-Bis-Boc-7-guanyl-Tic-OH (GTIC), a conformationally constrained amino acid with basic properties, has been synthesized in four steps. This amino acid can be incorporated into peptides using standard Fmoc solid phase synthesis, and to test its potential for biological activity applications, we prepared an analog of H-Dmt-Tic-NH2.
Keywords
unconventional amino acid , Synthesis , GTIC
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1644854
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