Author/Authors :
Chu، نويسنده , , Min and Mierzwa، نويسنده , , Ronald and He، نويسنده , , Ling and Xu، نويسنده , , Ling and Gentile، نويسنده , , Frank and Terracciano، نويسنده , , Joseph and Patel، نويسنده , , Mahesh and Miesel، نويسنده , , Lynn and Bohanon، نويسنده , , Samantha and Kravec، نويسنده , , Cynthia and Cramer، نويسنده , , Christina and Fischman، نويسنده , , Thierry O and Hruza، نويسنده , , Alan and Ramanathan، نويسنده , , Lata and Shipkova، نويسنده , , Petia and Chan، نويسنده , , Tze-Ming، نويسنده ,
Abstract :
Sch 382582 (1) and Sch 382583 (2), two novel pseudopeptides, were isolated from fermentation broth of Streptomyces sp. as bacteria peptide deformylase inhibitors. Structure elucidation of 1 and 2 was accomplished by extensive 2D NMR spectroscopic studies including NOESY, HMQC-TOCSY and HMBC experiments, and the relative stereochemistry was determined by X-ray crystallography. Both compounds displayed potent inhibitory activity against E. coli deformylase.
Keywords :
novel pseudopeptides , 1H and 13C NMR data , Purification , Structure elucidation
