Title of article
Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (−)-stipiamide
Author/Authors
Andrus، نويسنده , , Merritt B and Turner، نويسنده , , Timothy M and Updegraff، نويسنده , , Emily P and Sauna، نويسنده , , Zuben E and Ambudkar، نويسنده , , Suresh V، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
3819
To page
3822
Abstract
A series of five homodimeric polyethylene glycol (PEG) linked homodimers based on the multidrug resistance reversal agent (−)-stipiamide were made and tested for their ability to interact with P-glycoprotein, the protein responsible for multidrug resistance, using ATPase and photoaffinity displacement assays. Key reactions include a new alkoxide-mesylate displacement for the assembly of the PEG linkers and a double Sonogashira coupling reaction.
Keywords
polyethylene glycol , dimerization , etherification , Anticancer compounds , Multidrug resistance
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645052
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