Author/Authors :
Fakhfakh، نويسنده , , Mohamed A and Franck، نويسنده , , Xavier and Fournet، نويسنده , , Alain and Hocquemiller، نويسنده , , Reynald and Figadère، نويسنده , , Bruno، نويسنده ,
Abstract :
A library of 2-substituted quinolines was synthesized in solution from mixtures of Grignard reagents and a quinolinium salt. Grignard reagents were prepared in one pot, taking advantage of the entrainment method for their preparation from unreactive alkyl halides. Then mixtures of 2-alkylquinolines were readily accessible for biological tests or separated by centrifugal-partition chromatography (CPC) prior to the biological screening.
