Title of article
Synthesis of water-soluble aminosulfonamide ligands and their application in enantioselective transfer hydrogenation
Author/Authors
Bubert، نويسنده , , Christian and Blacker، نويسنده , , John and Brown، نويسنده , , Stephen M and Crosby، نويسنده , , John and Fitzjohn، نويسنده , , Steven and Muxworthy، نويسنده , , James P and Thorpe، نويسنده , , Tim and Williams، نويسنده , , Jonathan M.J. Williams، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
4037
To page
4039
Abstract
Water-soluble analogues of Noyoriʹs (1S,2S)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine and Knochelʹs (1R,2R)-N-(p-tolylsulfonyl)-1,2-diaminocyclohexane, containing an additional sulfonic acid group, have been synthesised. The ruthenium catalysed reduction of aromatic ketones using enantiomerically pure catalyst derived from water soluble ligands and [RuCl2(p-cymene)]2 has been examined. High enantioselectivity and moderate activity were observed in the 2-propanol/base system. The addition of water is necessary to stabilise the catalyst.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645223
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