Author/Authors :
Bubert، نويسنده , , Christian and Blacker، نويسنده , , John and Brown، نويسنده , , Stephen M and Crosby، نويسنده , , John and Fitzjohn، نويسنده , , Steven and Muxworthy، نويسنده , , James P and Thorpe، نويسنده , , Tim and Williams، نويسنده , , Jonathan M.J. Williams، نويسنده ,
Abstract :
Water-soluble analogues of Noyoriʹs (1S,2S)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine and Knochelʹs (1R,2R)-N-(p-tolylsulfonyl)-1,2-diaminocyclohexane, containing an additional sulfonic acid group, have been synthesised. The ruthenium catalysed reduction of aromatic ketones using enantiomerically pure catalyst derived from water soluble ligands and [RuCl2(p-cymene)]2 has been examined. High enantioselectivity and moderate activity were observed in the 2-propanol/base system. The addition of water is necessary to stabilise the catalyst.
