Title of article
Solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones
Author/Authors
Sun، نويسنده , , Qun and Zhou، نويسنده , , Xiaoming and Kyle، نويسنده , , Donald J، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
4119
To page
4121
Abstract
The solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones is described. Starting from Rink resin, acylation with 4-bromomethyl-3-nitrobenzoic acid and amination with primary amines, reduction with tin chloride and cyclization, the desired 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones have been synthesized in good yield and high purity.
Keywords
Combinatorial chemistry , 3 , solid-phase synthesis , 4-dihydro-2(1H)-quinazolinones , 3 , 4-dihydro-1H-quinazolin-2-thiones
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645290
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