Author/Authors :
Falck، نويسنده , , J.R and Reddy، نويسنده , , Y.Krishna and Haines، نويسنده , , Donovan C and Reddy، نويسنده , , Komandla Malla and Krishna، نويسنده , , U.Murali and Graham، نويسنده , , Sandra and Murry، نويسنده , , Barbara and Peterson، نويسنده , , Julian A، نويسنده ,
Abstract :
Cytochrome P450BM3 and its F87V mutant were exploited for a convenient, laboratory scale (1 mmol) preparation of 14(S),15(R)-epoxyeicosatrienoic acid [14(S),15(R)-EET] from arachidonic acid and (+)-leukotoxin B [(+)-12(S),13(R)-vernolic acid] from linoleic acid, respectively. Their enantiomers were accessed via a four-step chemical inversion.
Keywords :
Eicosanoids , epoxides , asymmetric synthesis , Biosynthesis , inversion reactions
