Title of article
10-Helical conformations in oxetane β-amino acid hexamers
Author/Authors
Claridge، نويسنده , , Timothy D.W and Goodman، نويسنده , , Jonathan M and Moreno، نويسنده , , Andres and Angus، نويسنده , , Donald and Barker، نويسنده , , Sarah F and Taillefumier، نويسنده , , Claude and Watterson، نويسنده , , Mark P and Fleet، نويسنده , , George W.J. Fleet، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
4251
To page
4255
Abstract
The first structural investigations were undertaken on a β-hexapeptide 7 in which the peptide backbone is constrained by cis-substituted oxetane rings. Detailed NMR studies in CDCl3 and C6D6 together with molecular mechanics conformational analysis identify a well-defined left-handed helical structure stabilised by 10-membered hydrogen-bonded rings. Comparison with two related hexapeptides 8 and 9 suggests a similar structural preference for these systems.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645395
Link To Document