Title of article
Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline
Author/Authors
Bois-Choussy، نويسنده , , Michèle and Cadet، نويسنده , , Sébastien and De Paolis، نويسنده , , Michael X. Zhu، نويسنده , , Jieping، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
4503
To page
4506
Abstract
Pictet–Spengler condensation of β-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1′-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated.
Keywords
1?-disubstituted tetrahydroisoquinoline , 1 , quaternary carbon , Pictet–Spengler reaction , diethyl oxomalonate , conformationally constrained amino acid
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645597
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