Author/Authors :
Fréville، نويسنده , , Stéphanie and Delbecq، نويسنده , , Philippe and Thuy، نويسنده , , Vu Moc and Petit، نويسنده , , Huguette and Célérier، نويسنده , , Jean Pierre and Lhommet، نويسنده , , Gérard، نويسنده ,
Abstract :
A new diastereoselective synthesis of 2,6-disubstituted piperidinic alkaloids is presented. Three natural compounds, the (−)-pinidinone 1a, the (+)-dihydropinidine 1b and the (−)-pinidinol 1c were prepared from optically pure (6R)-6-methylpiperidin-2-one 2. This method is based on the chemo- and diastereocontrolled reductions of an exocyclic β-enamino ketone.
