Title of article :
Synthesis of (4R*,5R*)-4-acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R*,4R*)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid: new inhibitors of influenza virus sialidases
Author/Authors :
Kerrigan، نويسنده , , Sean A and Smith، نويسنده , , Paul W and Stoodley، نويسنده , , Richard J، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
(4R*,5R*)-4-Acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R*,4R*)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid have been synthesised using a Diels–Alder tactic; both compounds are selective inhibitors of influenza A sialidase, the latter compound being particularly potent.
Keywords :
antivirals , cyclohexenes , Diels–Alder reactions , Nitro compounds , regioselection , dehydration
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
