Author/Authors :
Tempest، نويسنده , , Paul and Ma، نويسنده , , Vu and Thomas، نويسنده , , Samuel and Hua، نويسنده , , Zheng and Kelly، نويسنده , , Michael G and Hulme، نويسنده , , Christopher، نويسنده ,
Abstract :
The novel solution-phase synthesis of an array of biologically relevant benzimidazoles in a simple two-step procedure is revealed. Transformations are carried out in excellent yield by condensation of mono-Boc protected ortho-phenylene diamine and supporting Ugi reagents. Subsequent acid treatment and evaporation affords benzimidazoles in good to excellent yield. The described protocol represents a highly attractive solution-phase procedure for the rapid generation of benzimidazole libraries.
