Title of article
Direct synthesis of hydroxamates from carboxylic acids using 2-mercaptopyridone-1-oxide-based thiouronium salts
Author/Authors
Bailén، نويسنده , , Miguel A. and Chinchilla، نويسنده , , Rafael and Dodsworth، نويسنده , , David J and Nلjera، نويسنده , , Carmen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
5013
To page
5016
Abstract
Tetrafluoroborate and hexafluorophosphate thiouronium salts derived from 2-mercaptopyridone-1-oxide and tetramethylurea (TOTT and HOTT) or N,N′-dimethylpropyleneurea (TODT and HODT) convert carboxylic acids to Weinreb amides and N-methoxy or N-benzoxyamides in high yields by reaction with N,O-dimethylhydroxylamine and O-methyl- or O-benzyl-hydroxylamine hydrochlorides, respectively, in the presence of triethylamine or DIEA.
Keywords
Coupling reagents , amino acids , carboxylic acids , Hydroxamates , Weinreb amides
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645965
Link To Document