Title of article :
A convenient and high yield method to prepare 4-hydroxypyroglutamic acids
Author/Authors :
Zhang، نويسنده , , Xiaojun and Schmitt، نويسنده , , Aaron C. and Jiang، نويسنده , , Wen، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
RuO2/NaIO4 oxidation of N-Boc-4-silyloxy and 4-acetoxy proline methyl esters under ethyl acetate/water biphase condition gave N-Boc-4-silyloxy and 4-acetoxy pyroglutamic acid derivatives in high yields. Desilylation with TBAF afforded both cis- and trans-N-Boc-methyl-4-hydroxy pyroglutamates.
Keywords :
4-hydroxyl pyroglutamic acid , Mitsunobu reaction , Oxidation , N-acyliminium ion , Ruthenium dioxide
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
