Author/Authors :
Shin، نويسنده , , Jeong Ah and Cha، نويسنده , , Joo Hwan and Pae، نويسنده , , Ae Nim and Choi، نويسنده , , Kyung Il and Koh، نويسنده , , Hun Yeong and Kang، نويسنده , , Han-Young and Cho، نويسنده , , Yong Seo، نويسنده ,
Abstract :
Indium-mediated allylation reactions of α-ketoimides derived from Oppolzerʹs sultam were accomplished in aqueous THF in good yields and excellent diastereomeric excesses. It could be a useful method for the preparation of enantiopure t-α-hydroxy acids. When the substituent of α-ketoimides was changed from phenyl to thiophenyl or furyl group, diastereoselectivity decreased in comparison to N-phenyl derivatives, but changing solvent to aqueous ethanol provided improved levels of diastereoselectivity.
