Title of article
Synthesis and properties of novel pyrrolidinyl PNA carrying β-amino acid spacers
Author/Authors
Vilaivan، نويسنده , , Tirayut and Suparpprom، نويسنده , , Chaturong and Harnyuttanakorn، نويسنده , , Pongchai and Lowe، نويسنده , , Gordon، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
5533
To page
5536
Abstract
Novel pyrrolidinyl peptide nucleic acids comprising alternate sequences of nucleobase-modified d-proline and β-amino acid spacers selected from l-aminopyrrolidine-2-carboxylic acid, d-aminopyrrolidine-2-carboxylic acid, (1R,2S)-2-aminocyclopentane carboxylic acid and β-alanine were synthesized using solid phase methodology. Gel-binding shift assay revealed that only the homothymine PNA decamer bearing d-aminopyrrolidine-2-carboxylic acid spacer binds with (dA)10.
Keywords
Nucleic acids , DNA , ?-Amino acids , mimetics
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646372
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