Author/Authors :
Lewis، نويسنده , , Arwel and Stefanuti، نويسنده , , Ian and Swain، نويسنده , , Simon F and Smith، نويسنده , , Stephen A and Taylor، نويسنده , , Richard J.K. Taylor، نويسنده ,
Abstract :
A synthesis of apicularen analogue (−)-4 in 18 steps from d-glucal is reported. As (+)-4 has been converted into apicularen A in 8 steps, this constitutes a formal total synthesis of this potent naturally occurring anti-cancer agent.
