Title of article
A convenient route to 1-benzyl 3-aminopyrrolidine and 3-aminopiperidine
Author/Authors
Jean ، نويسنده , , Ludovic and Baglin، نويسنده , , Isabelle and Rouden، نويسنده , , Jacques and Maddaluno، نويسنده , , Jacques and Lasne، نويسنده , , Marie-Claire، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
5645
To page
5649
Abstract
1-Benzyl 3-aminopyrrolidine 1 and 1-benzyl 3-aminopiperidine 2 were prepared rapidly mainly in aqueous conditions in 55 and 75% yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The key step involved the Curtius rearrangement mediated by sodium nitrite and trifluoroacetic acid of the appropriate acylhydrazides. All the reactions (except LAH reductions) were performed in water.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646448
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