Author/Authors :
Jean ، نويسنده , , Ludovic and Baglin، نويسنده , , Isabelle and Rouden، نويسنده , , Jacques and Maddaluno، نويسنده , , Jacques and Lasne، نويسنده , , Marie-Claire، نويسنده ,
Abstract :
1-Benzyl 3-aminopyrrolidine 1 and 1-benzyl 3-aminopiperidine 2 were prepared rapidly mainly in aqueous conditions in 55 and 75% yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The key step involved the Curtius rearrangement mediated by sodium nitrite and trifluoroacetic acid of the appropriate acylhydrazides. All the reactions (except LAH reductions) were performed in water.
