• Title of article

    Preparation of polyfunctional pyridines by a palladium(0)-catalyzed cross-coupling of functionalized aryl Grignard reagents

  • Author/Authors

    Bonnet، نويسنده , , Véronique and Mongin، نويسنده , , Florence and Trécourt، نويسنده , , Francois and Quéguiner، نويسنده , , Guy and Knochel، نويسنده , , Paul، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2001
  • Pages
    3
  • From page
    5717
  • To page
    5719
  • Abstract
    Difunctionalized pyridines can be prepared by a Pd(0)-catalyzed cross-coupling of functionalized arylmagnesium compounds with chloro- or bromopyridines at temperatures as low as −40°C. An addition–elimination mechanism involving a palladate intermediate is proposed.
  • Keywords
    palladium-catalysis , pyridine synthesis , functionalized organomagnesium reagent , heterocycle synthesis
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2001
  • Journal title
    Tetrahedron Letters
  • Record number

    1646506