Title of article
Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 2: Chloromethylation of N-imine-protected amino acid esters
Author/Authors
Onishi، نويسنده , , Tomoyuki and Nakano، نويسنده , , Takashi and Hirose، نويسنده , , Naoko and Nakazawa، نويسنده , , Masakazu and Izawa، نويسنده , , Kunisuke، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
5887
To page
5890
Abstract
Chloromethylation of N-imine-protected amino acid esters followed by acid hydrolysis gave α-aminoalkyl-α′-chloromethylketone as a HCl salt form in good yield without racemization. The amino group was conveniently protected with carbamate protecting reagents to give various useful intermediates for the protease inhibitors.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646634
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