Title of article
A short synthetic route to nordihydroguaiaretic acid (NDGA) and its stereoisomer using Ti-induced carbonyl-coupling reaction
Author/Authors
Gezginci، نويسنده , , Mikail H and Timmermann، نويسنده , , Barbara N، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
6083
To page
6085
Abstract
A rapid synthetic approach to natural meso-nordihydroguaiaretic acid (NDGA) and its non-meso isomer is described from (3,4-dimethoxyphenyl)acetone using as a key step the low-valent Ti-induced carbonyl-coupling reaction of the ketone. The method involves a simple separation of the E- and Z-isomers that result from the dehydroxylation of the diol product of the coupling. The present approach allows the preparation of various analogs of NDGA.
Keywords
4-dimethoxyphenyl)acetone , (3 , natural products synthesis , Nordihydroguaiaretic acid , carbonyl coupling , NDGA , TI
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646771
Link To Document