Radical-mediated stereoselective synthesis of (+)-dihydrocanadensolide and (−)-3-epi-dihydrocanadensolide from d-xylose

An intramolecular radical cyclisation protocol on 5-hexenyl systems was utilised for the first time in a synthesis of (+)-dihydrocanadensolide and its C-3 epimer. This study also revealed the effect of the additional stereocentre at the 2′-position of the radical systems.