Author/Authors :
Imai، نويسنده , , Hiroto and Uehara، نويسنده , , Hisatoshi and Inoue، نويسنده , , Masayuki and Oguri، نويسنده , , Hiroki and Oishi، نويسنده , , Tohru and Hirama، نويسنده , , Masahiro، نويسنده ,
Abstract :
A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal CO bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F ring.
Keywords :
ciguatoxin , polyethers , Stereocontrolled synthesis , ring-closing metathesis , acetal cleavage , Radical reaction
